| Sol Negro ©1988 Opera Soft Action
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| Solomon's Key ©1988 U.S. Gold Ltd. Action Strategy
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| Solus ©1988 Matt Gruson Adventure Interactive Fiction
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| Son of Tetris Project, The ©1988 WRW Strategy Action
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| Sonar ©1988 Unknown Strategy Action
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| Sons of Liberty ©1988 Strategic Simulations, Inc. Strategy
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| Sorcerer Lord ©1988 Personal Software Services Strategy
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| Sorry! ©1988 Joe Glockner Strategy
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| Space Adventure ©1988 Fireball Software Ltd. Adventure
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| Space Flees ©1988 Independent Software Action
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| Space Pirate ©1988 Michael J. Wanta Strategy Action
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| Space Quest II- Chapter II - Vohaul's Revenge ©1988 Sierra On-Line, Inc. Adventure
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| Space Racer ©1988 Broderbund Software, Inc. Racing - Driving
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| Space Risk! ©1988 MicroComputing Concepts Strategy
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| Space Station Oblivion ©1988 Epyx, Inc. Action Strategy
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| Speedball ©1988 Spotlight Software Action Sports
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| Spell Games ©1988 TexaSoft Educational
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| Spelling Fun 1 ©1988 Reckon Software Publishers Educational
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| Spiderbot ©1988 Epyx, Inc. Action
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| Splitz ©1988 I.B. Magazette Action
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| Sporting News Baseball ©1988 Designer Software Sports
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| Spy vs. Spy III- Arctic Antics ©1988 First Star Software, Inc. Action Strategy
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| Squynchia Adventure ©1988 M. & T. Frank Adventure
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| Star Command ©1988 Strategic Simulations, Inc. RPG
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| Star Empire ©1988 Videodata Inc., First Row Software Publishing, Inc. Action
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| Star Goose! (CGA) ©1988 Logotron Ltd Action
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| Star Goose! (EGA) ©1988 Logotron Ltd Action
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| Star Saga One- Beyond the Boundary ©1988 Electronic Arts, Inc. RPG
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| Star Trek- First Contact ©1988 Simon & Schuster Interactive Adventure Interactive Fiction
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| Star Trek- The Last Generation ©1988 Xordanbhorgh, Inc. Adventure
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| Star Trek- The Rebel Universe (CGA) ©1988 Simon & Schuster Interactive Simulation Strategy
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| Star Trek- The Rebel Universe (EGA) ©1988 Simon & Schuster Interactive Simulation Strategy
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| Stardust ©1988 Topo Soft Action
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| Starquake ©1988 ShareData, Inc. Action
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| Stellar Crusade ©1988 Strategic Simulations, Inc. Simulation Strategy
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| Stocker ©1988 Capcom U.S.A., Inc. Racing - Driving
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| Strategic Defence Initiative ©1988 Georg Zimmer Action
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| Street Fighter ©1988 Capcom Co., Ltd. Action
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| Strike Fleet ©1988 Electronic Arts, Inc. Simulation Strategy
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| Strike Force Harrier ©1988 Mirrorsoft Ltd. Simulation
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| Strip Poker II ©1988 Artworx Software Co, Inc. Strategy Cards Adult
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| Strip Poker II+ ©1988 Anco Strategy Cards Adult
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| Suju ©1988 Raymond M. Buti Action
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| Summer Olympiad ©1988 Thunder Mountain Sports
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| Super Cube ©1988 M&M Software Strategy
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